As the game opens, Huey runs to his uncle Scrooge McDuck with a torn piece of paper, which is a piece of a treasure map drawn by Fergus McDuck. Inspired to discover the hidden treasure left by Fergus, Scrooge starts an expedition to find the missing pieces, unaware that his archenemy Flintheart Glomgold is also after the lost treasure of McDuck.
Scrooge travels to Niagara Falls, a pirate ship in the Bermuda Triangle, Mu, Egypt and Scotland. Each area has its own unique treasure that is guarded by a boss. After all five main stages are cleared, Webby is kidnapped by Glomgold and held for ransom on the pirate ship in the Bermuda Triangle. Scrooge arrives and gives Glomgold the treasures, only to discover that this "Glomgold" is actually a shapeshifting robot called the D-1000 programmed to destroy him. After the D-1000 is defeated, Glomgold sinks the ship and tries to take Scrooge and the treasures with it.
